Therefore, independent, large-scale studies are warranted to more accurately assess the efficacy and overall safety of using intravaginal alprostadil for cervical ripening and labor induction. Additional clinical experience should also help to determine the best regimen and method of administration.
From the data currently available, it appears that either a or microgram dose one-fourth or one-half of a microgram tablet inserted into the posterior vaginal fornix and repeated at hour intervals if needed, is a clinically effective regimen, and is associated with the least amount of adverse effects and complications.
As with all labor inductions, uterine contractions and fetal heart rate should be monitored carefully throughout the procedure. Abstract Misoprostol is an effective agent for cervical ripening and induction of labor.
Publication types Review. Substances Oxytocics Misoprostol Dinoprostone. A systematic review and meta-analysis evaluating medical therapeutic abortion in the first trimester found that oral dosing was the least effective route of administration. In the review of five RCTs, rates of nausea and vomiting were similar for all comparisons, but rates of diarrhea sometimes differed. In the meta-analysis of 18 RCTs, different dosing regimens and routes of administration generally yielded similar adverse effect profiles.
The review of RCTs combining misoprostol with mifepristone for therapeutic abortion found that vaginal dosing tended to be better tolerated. Used with permission. Already a member or subscriber? Log in. Interested in AAFP membership? Learn more. Address correspondence to Jon O. Reprints are not available from the authors. Medical treatments for incomplete miscarriage. Cochrane Database Syst Rev.
Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis. Sci Rep. Medical methods for first trimester abortion. Members of the network select questions based on their relevance to family medicine. The impact of tubal ectopic pregnancy in Papua New Guinea--a retrospective case review. BMC Pregnancy Childbirth. Int J Gynaecol Obstet.
Methods of induction of labour: a systematic review. Oral misoprostol for induction of labour at term: randomised controlled trial. Keirse MJ. Prostaglandins in preinduction cervical ripening. Meta-analysis of worldwide clinical experience. J Reprod Med. Song J. Use of misoprostol in obstetrics and gynecology. Obstet Gynecol Surv. Misoprostol: a quarter century of use, abuse, and creative misuse.
Cytotec Misoprostol. Accessed 8 June Papua new Guinea national census. Google Scholar. Ethical challenges in integrating patient-care with clinical research in a resource-limited setting: perspectives from Papua New Guinea.
BMC Med Ethics. Trends in maternal and perinatal mortality in a provincial Hospital in Papua new Guinea: a 6-year review.
PNG Med J. Uterine hyperstimulation. The need for standard terminology. Low-dose oral misoprostol for induction of labor: a systematic review. Obstet Gynecol. Titrated oral compared with vaginal misoprostol for labor induction: a randomized controlled trial. A comparison of misoprostol and prostaglandin E2 gel for preinduction cervical ripening and labor induction. Am J Obstet Gynecol. The routine use of oxytocin after oral misoprostol for labour induction in women with an unfavourable cervix is not of benefit.
A comparison of various routes and dosages of misoprostol for cervical ripening and the induction of labor. WHO recommendations for induction of labour.
Geneva: WHO press; Oral misoprostol for induction of labour. Cochrane Database Syst Rev. WHO global survey on maternal and Perinatal health. Induction of labour data. Decision to incision time for emergency caesarean section: a prospective observational study from a regional referral hospital in Papua New Guinea.
Article Google Scholar. Download references. We also acknowledge the assistance of the special-care nursery team, theatre and anaesthetic teams as well as the management of Modilon Hospital for making this study possible. This study did not receive any source of funding from the public, private or not-for-profit sector.
Data from this study can be retrieved by the principal investigators upon request and approval from the Modilon Hospital Ethics Committee. Marilyn Morris, John W. You can also search for this author in PubMed Google Scholar. JWB conceived the study.
MM wrote the first draft of the paper. JWB and ML edited the manuscript and produced the final version. All authors approved the final version of the manuscript before submission. Correspondence to John W.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions. Morris, M. Safety and effectiveness of oral misoprostol for induction of labour in a resource-limited setting: a dose escalation study. BMC Pregnancy Childbirth 17, Download citation. Received : 10 February Accepted : 04 September Published : 08 September Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.
Skip to main content. Search all BMC articles Search. Download PDF.
0コメント