One important side effect is the possibility of multiple births. The chance of having more than twins is rare. If your symptoms get worse, you should definitely seek medical attention by contacting myself, your GP or nearest emergency department. In rare cases, you may need to be hospitalized. Hospitalization may include receiving fluids intravenously through an IV , and they may remove some of the excess fluids in your belly via a needle.
You may also be kept in the hospital for careful monitoring until your symptoms lessen. Usually, symptoms will decrease and go away once you get your period. If you get pregnant, though, your symptoms may be prolonged, and it may take several weeks to feel completely better. Pregnancy can also make the symptoms worse. Instructions for the use of Clomid. Ultrasound monitoring at this stage also serves to measure the endometrial uterine lining and to make sure the clomiphene itself is not having any adverse effects on the endometrium see Clomiphene side effects, below , At this stage, patients are also asked to use an ovulation predictor kit to test for a surge in LH hormone, indicating imminent ovulation.
In most cases, patients are given an injection of hCG human chorionic gonadotropin also known as Ovidrel. This hormone initiates the release of the egg ovulation and the development of the corpus luteum, which will help the body to produce progesterone. Ovulation usually occurs approximately hours after the hCG injection. After ovulation, a form of the hormone progesterone is given via vaginal tablets or gel in order to support the endometrial uterine lining and prepare it for the fertilized egg.
Patients are asked to take a home pregnancy test urine test two weeks after ovulation. If the home test is positive, a blood test will be performed to confirm the results. Clomiphene can sometimes decrease cervical mucus production, which may make it impossible for the sperm to swim through the cervix into the uterus. To get around this potential problem, intrauterine insemination IUI may be advised so that cervical mucus may be bypassed altogether.
If the lining is too thin, the embryo cannot implant successfully. This side effect tends to occur with repeated use or with higher doses of medication. Endometrial thinning will stop once clomiphene treatment concludes. An alternative therapy often recommended in these situations is a medication called Letrozole, which has a milder effect on the hormonal system.
Letrozole temporarily lowers estrogen levels, prompting the pituitary gland to increase FSH and LH production and promote ovulation. While letrozole is not yet FDA-approved for ovulation induction, widely conducted studies indicate that there is no detriment to this treatment option. This condition is rare in clomiphene treatment, and more common with use of gonadotropin medications.
Ovarian hyperstimulation syndrome is marked by abdominal bloating, nausea and diarrhea, and in more severe cases, symptoms including shortness of breath, difficulty with urination and chest pain.
Adjustments can be made for those who hyperstimulate by decreasing medication and shortening the treatment cycle. The symptoms of hyperstimulation begin about a week after ovulation. Mild cases last about a week and usually respond to hydration and careful monitoring.
In general, ovarian hyperstimulation is highly unlikely, given careful monitoring of follicle development. Multiple pregnancy may be a risk with clomiphene treatment. If an ultrasound scan reveals 3 or more mature follicles eggs indicating that a high multiple pregnancy is possible, patients may be advised to consider whether or not they would undergo embryo reduction, should a triplet pregnancy occur.
If this procedure is not desired, or if multiple pregnancies would pose a physical or emotional challenge, patients may be recommended to forego attempts to conceive during this cycle.
Let's Connect. Learn About Pacific Fertility Center. Enter search terms Close search form. Translate page. Some reproductive specialists prescribe Clomid as well. Day three, four, or five is typical for a Clomid start date. Doctors will usually prescribe one, two, three, or sometimes four pills to be taken at the same time each day, depending on how they think you will respond to the medicine. Some doctors will want you to come back for blood work to measure hormone levels or a transvaginal ultrasound to look at your ovarian follicles.
This information can help them determine when you should begin having intercourse or have an intrauterine insemination. It can also help them determine the appropriate dose for your next cycle. Your doctor may extend this if it takes a few cycles before they find the dose that works for you.
Clomid is often prescribed to women with polycystic ovary syndrome, or PCOS, which is a syndrome that can cause irregular or absent ovulation. Not everyone will respond to this medication.
Women with primary ovarian insufficiency, or early menopause, and women with absent ovulation due to low body weight or hypothalamic amenorrhea are most likely to not ovulate when taking Clomid. Women with these conditions may need more intensive infertility treatment.
Clomid is usually covered by your health insurance, when other fertility medications may not be. If you do not have insurance coverage for your medication, or are having difficulty paying for it, speak with your doctor about your options.
While this medication is generally pretty safe, there are some side effects that you should be aware of. They include:. There is a slightly higher risk of having a multiple pregnancy when taking Clomid. This rate is around 7 percent for twins, and below 0. You should speak with your doctor about this risk and whether you are able to carry twins or other multiples. They may suggest more aggressive monitoring if you are unwilling or unable to carry a twin pregnancy. Clomid can also reduce the amount and quality of your cervical mucus.
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