Mozolewska, Adam K. Delbem, Christodoulos A. Scheraga, Jeffrey Skolnick, Silvia N. Crivelli and Foldit Players. WeFold: a coopetition for protein structure prediction.
Proteins Christopher B. Eiben, Justin B. Siegel, Jacob B. Shen, Foldit Players, Barry L. Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nature Biotechnology The impact of tutorials on games of varying complexity.
Algorithm discovery by protein folding game players. High-resolution structure of a retroviral protease folded as a monomer. Acta Crystallographica Crystal structure of a monomeric retroviral protease solved by protein folding game players.
Nature Structural and Molecular Biology Analysis of social gameplay macros in the Foldit cookbook. Predicting protein structures with a multiplayer online game. Nature The challenge of designing scientific discovery games. The Foldit players have designed a few real proteins!
See this link to view them! Foldit has been in dozens of publications over the years - to list them all would take a page of their own. For a sampling, please see our Center for Game Science page. Check out the Rosetta Home Screensaver to see how computers fold proteins using distributed computing. Rules for Foldit community members can be found here. You can listen to all episodes of the Let's Foldit podcast here. Thank you for using Foldit in your classroom!
We have put together a set of instructions to assist you in setting up your students to play Foldit. The Foldit terms of service and consent can be found here. You can find the researchers and supporters associated with this study on the game's credits page. The Science Behind Foldit Foldit is a revolutionary crowdsourcing computer game enabling you to contribute to important scientific research.
This page describes the science behind Foldit and how your playing can help. Page Contents: What is protein folding? Why is this game important? This is an example of a puzzle that a human can see the obvious answer to - fix the sheet that is sticking out!
Create new account Request new password. Tackle a different kind of research challenge with new tools for designing small molecules in Foldit! NEWS - New tools for small molecule design. A fully-satisfied H-bond network helps to prevent off-target assembly. Take a look for yourself in the November Design of the Month sandbox puzzle. Hey everyone! In case you missed it, check out the latest Office Hour here! Compare playing Foldit to playing other games. There are no time-critical kinds of things, other than approaching the deadline for a particular puzzle closing.
When we started, we often thought about it as a 3D Tetris. You want to remove all the empty space from the interior of the protein by packing everything in as tightly as possible. It definitely requires some kind of 3D spatial reasoning to follow.
You can build the protein up, more or less from scratch, starting with a scaffold that you can change to be whatever you want, building it with whatever little molecular subcomponents that you feel like.
There were all these different variables and possibilities to consider. Before we released the game, we spent about a year coming up with prototypes.
The game development team was going back and forth with the biochemists in the Baker Lab here at the University of Washington, seeing what they thought would be useful and watching people play the game to see where they got stuck, where they got confused, what kinds of things they liked to do and what kinds of problems they could solve. We released Foldit about four years ago online, after a year of alpha testing. The game records the structure and the moves that the players do, and we get data that we use to improve the game in every aspect, from the quality of the scientific results that are coming back to how long people play the introductory levels that are supposed to teach the game.
The whole game is like an ongoing, continuous experiment. We release updates every couple of weeks with new features. Every week, we publish a different set of puzzles. What sort of people like playing this game, which requires quite a time investment to get to levels where they are working on a real-life protein? A lot of different people are interested in playing the game.
Most of the players are from the United States, but there are a large number from Europe, Australia, New Zealand and other countries. I think that a lot of the players are brought into the game or at least stick around for a number of reasons: They are motivated by the sense of purpose of contributing to science.
A Foldit introductory level protein, introducing protein design. The player can change the structure of the orange sidechains. By making them smaller, the spiky red clashes can be fixed. Do you get such a broad group because the game provides a variety of motivations, which in turn draw in a lot of different people? We built the game using many different rewards or motivations. It's designed to encourage competition, because everyone is trying to fold their version of the protein better than everyone else to get the highest score.
Players can form teams to work together. What if the world were all a game? How games will change the world. Retroviral proteases have a critical role in the development of an Aids virus. Complex structures. Protein folding had proved to be one of the more popular uses for distributed computing.
Published 21 June
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